线粒体病的母系遗传

本文综述了线粒体病的特点,并对线粒体病的母系遗传方式进行了分析。     

蒙中西医结合治疗慢性前列腺炎伴性功能障碍临床观察

目的：探讨蒙中西医结合治疗慢性前列腺炎伴性功能异常的疗效．方法：对50例慢性前列腺炎伴性功能异常患者的临床资料进行系统的分析、总结．结果：经过现代医学和传统医学方法诊断治疗的50例慢性前列腺炎伴性功能异常患者的临床症状明显好转或痊愈．结论：中蒙西医结合治疗慢性前列腺炎伴性功能障碍是目前行之有效的治疗手段之一．     

Application of the phylogenetic analysis in mitochondrial disease study

Mitochondrial disease currently received an increasing concern. However, the case-control design commonly adopted in this field is vulnerable to genetic background, population stratification and poor data quality. Although the phylogenetic analysis could help solve part of these problems, it has not received adequate attention. This paper is a review of this method as well as its application in mitochondrial disease study.     

动物线粒体基因组全序列测定的研究策略

动物线粒体基因组全序列测定是近年来生物学研究中的一个热点。科学技术的发展,对动物线粒体基因组全序列测定的研究策略也产生了深远的影响。在此对几种在动物线粒体基因组全序列测定中常用的几种策略进行了综述,并对其优缺点进行了比较分析。     

线粒体蛋白组研究进展

线粒体蛋白组是指在线粒体中出现的所有蛋白质的集合,包括线粒体自身基因组编码的和 由核基因组编码的蛋白质.线粒体作为真核生物的重要细胞器,它参与去除氧化、产生能量和还原 性物质等等一些重要的生命活动过程.这些功能都依赖于线粒体蛋白组中的蛋白河的相互作用.要 对其有一个较为全面的认识,就必须对其蛋白组进行广泛且深入的研究.根据现有的一些研究成 果,对线粒体蛋白组在起源与进化、跨膜运输、研究方法和计算机预测作了简要综述.     

凯时联合甲钴铵治疗32例糖尿病患者勃起功能障碍

目的:观察脂化前列腺素1(凯时)与甲钴胺联合应用治疗糖尿病患者勃起功能障碍(ED)的疗效。方法:将32例勃起功能障碍的糖尿病患者给予凯时与甲钴胺联合治疗,治疗前后根据国际勃起功能指数表(IIEF-5)患者进行自我评分。结果:32例患者接受凯时与甲钴铵治疗后,患者IIEF-5总评分和各问题的评分均显著高于治疗前(P<0.05或0.01)。结论:凯时联合甲钴铵治疗糖尿病合并ED具有良好的效果。     

Geographic populations of the medfly may be differentiated by mitochondrial DNA variation

Restriction enzyme cleavage sites of mitochondrial DNA (mtDNA) from the Mediterranean fruit fly were found to vary among introduced populations in the Neotropics. The survey included samples from 15 established natural populations and 5 laboratory cultures from Hawaii, Central America, South America and West Africa and samples from recent California infestations (1989, 1991). Based on restriction fragment length polymorphisms from 2 enzymes, Hawaii is an unlikely source for the 1989 and 1991 California infestations. Interpopulational variation in mtDNA demonstrates the potential for the technique to trace the process of colonization (geographic spread) by this insect.     

Cytosolic factors in mitochondrial protein import

In vitro import studies have confirmed the participation of cytosolic protein factors in the import of various precursor proteins into mitochondria. The requirement for extramitochondrial adenosine triphosphate for the import of a group of precursor proteins seems to be correlated with the chaperone activity of the cytosolic protein factors. One of the cytosolic protein factors is hsp70, which generally recognizes and binds unfolded proteins in the cytoplasm. Hsp70 keeps the newly synthesized mitochondrial precursor proteins in import-competent unfolded conformations. Another cytosolic protein factor that has been characterized is mitochondrial import stimulation factor (MSF), which seems to be specific to mitochondrial precursor proteins. MSF recognizes the mitochondrial precursor proteins, forms a complex with them and targets them to the receptors on the outer surface of mitochondria.     

Septation and fragmentation inOedogonium mitochondria as different and independent effects of dimethyl sulfoxide (DMSO) treatment

Summary Oedogonium cardiacum Wittrock, a filamentous green alga, was treated with DMSO. The substance induced active swelling and fragmentation of mitochondria at both 5 and 7.5%. Septa were observed at 7.5% only and were not identical with the fragmentation sites. Thus it is concluded that internal partition by septa is not a prerequisite for mitochondrial fragmentation or division.Acknowledgment. This work was supported by the Österreichische Nationalbank, Jubiläumsfondsprojekt No. 1927.     

Role of serotonin in the hepato-gastroIntestinal tract: an old molecule for new perspectives

Beside its role as a neurotransmitter in the central nervous system, serotonin appears to be a central physiologic mediator of many gastrointestinal (GI) functions and a mediator of the brain-gut connection. By acting directly and via modulation of the enteric nervous system, serotonin has numerous effects on the GI tract. The main gut disturbances in which serotonin is involved are acute chemotherapy-induced nausea and vomiting, carcinoid syndrome and irritable bowel syndrome. Serotonin also has mitogenic properties. Platelet-derived serotonin is involved in liver regeneration after partial hepatectomy. In diseased liver, serotonin may play a crucial role in the progression of hepatic fibrosis and the pathogenesis of steatohepatitis. Better understanding of the role of the serotonin receptor subtypes and serotonin mechanisms of action in the liver and gut may open new therapeutic strategies in hepato-gastrointestinal diseases. Received 15 August 2007; received after revision 1 November 2007; accepted 5 November 2007